What CJC-1295 (no DAC) is
CJC-1295 (no DAC) is a synthetic peptide of 29 amino acids based on the first 29 residues of human growth-hormone-releasing hormone (GHRH), the fragment that retains the full receptor activity of the 44-residue native hormone. Four positions are substituted relative to the native sequence: D-alanine replaces alanine at position 2, glutamine replaces asparagine at position 8, alanine replaces glycine at position 15 and leucine replaces methionine at position 27. These changes protect the peptide from cleavage by dipeptidyl peptidase-4, from deamidation and from methionine oxidation, and the molecule is often called modified GRF (1–29).
The name CJC-1295 originally belonged to a compound developed by ConjuChem that carried the same substituted sequence plus a drug affinity complex, a reactive linker on the C-terminal lysine that binds the peptide covalently to serum albumin and extends its half-life to several days. The material on this page lacks that linker. It is the bare substituted sequence, with an amidated C-terminus, an average molecular weight of approximately 3,368 g/mol and the CAS number 863288-34-0.
The published literature on the compound, with references, is collected in the monograph.
What you receive
Each vial contains CJC-1295 (no DAC) as a white lyophilised powder, sealed with a flip-off cap over a crimped stopper, in the net quantity stated on the label: 5 or 10 mg. There is no carrier, mannitol or other excipient unless the batch certificate says otherwise. The batch number is printed on the label and matches the certificate in our register.
Reading the certificate for a CJC-1295 (no DAC) batch
Three results matter. Purity by reversed-phase HPLC is reported as the area of the main peak against all peaks and should be above 98% for a well-made lot. Identity by LC-MS is reported as the observed mass against the expected mass of about 3,368 Da. This figure is the one to check carefully, because the DAC-linked form is several hundred daltons heavier and native sermorelin is about ten daltons lighter; a mass match within instrument tolerance confirms that you have the substituted, linker-free sequence. Net peptide content gives the milligrams of peptide actually in the vial, as distinct from the nominal fill, which is the figure you need when preparing stock solutions.
Peptides of this length usually show a few small early-eluting peaks on HPLC from deletion sequences, normal at the sub-1% level in a fresh lot. Our guide to reading a certificate of analysis walks through annotated examples.
Storage and handling
Sealed vials should be kept refrigerated at 2 to 8 °C and protected from light; for storage beyond a few months, −20 °C is preferable. The lyophilised powder is stable for well over a year under those conditions. Allow the vial to reach room temperature before opening so that condensation does not form on the powder. The peptide dissolves readily in water or dilute buffer at neutral pH. Reconstituted solutions should be prepared fresh or aliquoted and frozen, since the glutamine at position 8 deamidates slowly in solution; the storage and stability guide covers solvents, concentrations and freeze-thaw behaviour.