What survodutide is
Survodutide is a synthetic lipidated peptide that activates both the glucagon receptor (GCGR) and the glucagon-like peptide-1 receptor (GLP-1R). It was discovered at Boehringer Ingelheim in collaboration with Zealand Pharma and carries the development code BI 456906. Along with mazdutide it represents the glucagon/GLP-1 pairing of receptors, a different combination from the GIP/GLP-1 pairing of tirzepatide, and it sits between the single-receptor GLP-1 analogues and the triple agonist retatrutide in receptor coverage.
The molecule is built on the sequence of glucagon rather than GLP-1, with substitutions that confer activity at GLP-1R, protection against DPP-4 cleavage near the N-terminus, and a fatty diacid attached to a lysine side-chain through a linker. As with the other long-acting peptides in this family, the diacid binds reversibly to serum albumin and gives the compound a half-life of several days in the published pharmacokinetics. No CAS registry number has been assigned to survodutide in the sources we rely on, so we do not quote one; identity is established by sequence and LC-MS instead.
The published literature on the compound, with references, is collected in the monograph.
What you receive
Each vial contains survodutide as a white to off-white lyophilised powder, sealed with a flip-off cap over a crimped stopper, in the net quantity stated on the label: 10 mg. There is no carrier, mannitol or other excipient unless the batch certificate says otherwise. The batch number is printed on the label and matches the certificate in our register.
Reading the certificate for a survodutide batch
Purity by reversed-phase HPLC is reported as the area of the main peak against all peaks and should be above 98% for a lipidated peptide of this kind, with the best lots above 99%. Identity by LC-MS is reported as the observed mass against the expected mass of the full lipidated sequence. The fatty diacid and linker contribute several hundred daltons, so a batch in which the lipid is missing or truncated fails this check clearly. Net peptide content gives the milligrams of peptide actually present, after allowing for the water and counter-ions that a lyophilised powder retains.
Glucagon-based sequences carry a methionine and a tryptophan, so oxidised variants are the impurities to look for alongside the usual deletion sequences; both elute close to the main peak. At the sub-1% level these are normal. Our guide to reading a certificate of analysis shows annotated examples, and HPLC and LC-MS explained describes the methods.
Storage and handling
Sealed vials should be kept refrigerated at 2 to 8 °C and protected from light; −20 °C is preferable for storage beyond a few months, and the lyophilised powder is stable for well over a year under those conditions. The lipidated chain is hygroscopic, so allow the vial to reach room temperature before opening. Glucagon-family peptides are poorly soluble near neutral pH and dissolve more readily in mildly acidic or mildly alkaline buffers, so acetic acid 0.6% is a reasonable first choice of solvent for in-vitro work. Solutions should be prepared fresh or aliquoted and frozen; the storage and stability guide covers solvents, concentrations and freeze-thaw behaviour.